بررسی مروری تکنیک‌های بهبود یکنواختی توزیع دز در تابش فوتونی تمام بدن (TBI) با هندسه درمان مخالف و موازی قدامی و خلفی

نویسندگان

1 دانشگاه علوم پزشکی تهران

2 مرکز تحقیقات ضایعات مغزی و نخاعی بیمارستان امام خمینی

3 انستیتو کانسر بیمارستان امام خمینی

چکیده

تابش تمام بدن (TBI) یکی از انواع درمان های رادیوتراپی با میدان خارجی است که معمولا همراه با شیمی درمانی برای سرکوب سیستم ایمنی و آمادگی بیمار قبل از پیوند مغز استخوان انجام می‌شود. طبق توصیه AAPM در TBI وجود یکنواختی در توزیع دز امری ضروری است و لذا تغییرات دز در طول بدن باید در محدوده %10± دز تجویزی قرار داشته باشد. به طور کلی TBI در دو هندسه درمان مخالف و موازی قدامی و خلفی و مخالف و موازی جانبی انجام می‌شود. به علت آن‌که هندسه مخالف و موازی قدامی و خلفی نسبت به هندسه دوجانبه یکنواختی بهتری دارد، بهبود یکنواختی در این تکنیک ساده تر است. تاکنون تکنیک‌های مختلفی ازجمله استفاده از جبرانگرهای بافت، تکنیک‌های رادیوتراپی دینامیک و... برای بهبود یکنواختی توزیع توسط مراکز مختلف در سراسر دنیا مورد استفاده قرار گرفته‌اند. هدف از این مطالعه، بررسی مروری بر تکنیک‌های بهبود یکنواختی توزیع دز در تابش فوتونی تمام بدن با هندسه درمان مخالف و موازی قدامی و خلفی است.
 

کلیدواژه‌ها


عنوان مقاله [English]

Review of techniques for improving the uniformity of dose distribution in total body irradiation (TBI) with parallel – opposed anterior and posterior geometry

نویسندگان [English]

  • Elham hoseinnezhad 1
  • ghazale geraily 1
  • mosafa farzin 2
  • mahbod esfahani 3
  • tahere hadisiniya 1
1
2
3
چکیده [English]

      Total body irradiation (TBI) is a kind of external beam radiotherapy which is used in conjunction with chemotherapy with the purpose of immunosuppression before bone marrow transplantation. As recommended by AAPM dose distribution uniformity in TBI is very important and dose variation must be within ±10% of prescription dose. Patients treatment geometry for TBI techniques fall into two common categories: parallel-opposed anterior/posterior lateral total body irradiation and parallel-opposed lateral total body irradiation. So far several techniques such as use of tissue compensator, dynamic TBI delivery, etc. where implemented in different department around the world to improve dose distribution uniformity. The propose of this paper is to review several techniques that are used around the world for dose uniformity improvement in parallel opposed anterior posterior TBI.

کلیدواژه‌ها [English]

  • total body irradiation
  • tratment geometry
  • compensator
  • translation couch technique
  • sweeping beam technique
  • uniformity
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