بررسی و مقایسه دزیمتر ژل پلیمری MAGICA و PAGATA جهت مقاصد پزشکی هسته‌ای

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه مهندسی پرتوپزشکی، دانشکده فنی مهندسی ، واحد لاهیجان ، دانشگاه آزاد اسلامی ، لاهیجان ، ایران

10.22052/rsm.2024.254439.1051

چکیده

محاسبه توزیع فضایی دز در طول پرتودرمانی می‌تواند به پزشک‌ها در درمان بهتر اندام سرطانی و کاهش دز اندام‌های حساس اطراف آن، کمک کند. دزیمترهای ژل پلیمری معادل بافت حاوی مواد شیمیایی حساس به پرتو هستند که تحت تابش به‌صورت تابعی از دز جذبی، پلیمریزه شده و اطلاعات فضایی توزیع دز با تصویربرداری از ژل تابش دیده، قابل‌استخراج است. در این مطالعه، با استفاده از کد مونت‌کارلو MCNPX و فانتوم ORNL، ابتدا دز دریافتی ریه‌ها، کبد، پستان، معده، طحال و کلیه‌ها در حین پرتودرمانی هدفمند بافت سرطانی ریه با استفاده از ید-131 شبیه‌سازی شد. سپس ژل دزیمترهای MAGICA و PAGATA در بافت‌های هدف قرار داده شده و دز دریافتی آن‌ها مجدداً بررسی شد. نتایج این شبیه‌سازی‌ها نشان می‌دهد که دز دریافتی بافت ریه‌ها، کبد، پستان، معده، طحال و کلیه‌ها با نتایج ژل دزیمترهای MAGICA و PAGATA قابل‌مقایسه هستند؛ بنابراین از این ژل دزیمترها می‌توان در دزیمتری درمان با ید-131 در فانتوم‌های فیزیکی، استفاده کرد.

کلیدواژه‌ها

عنوان مقاله [English]

Evaluation and comparison of MAGICA and PAGATA polymer gel dosimeters for nuclear medicine purposes

نویسندگان [English]

  • Mohadeseh Falahatkar
  • Mahyar Nirouei
  • Alireza Azadbar
Department of Nuclear Engineering, Lahijan Branch, Islamic Azad University, Lahijan, Iran
چکیده [English]

Calculation of the dose spatial distribution during radiation therapy can help doctors to better treat the cancerous organ and reduce the dose of sensitive organs around it. Tissue equivalent polymer gel dosimeters consist of radiation-sensitive chemicals that are polymerized under irradiation as a function of absorbed dose, and the spatial information of dose distribution can be extracted by imaging the irradiated gel. In this study, using MCNPX Monte Carlo code and ORNL phantom, the received dose of lungs, liver, breast, stomach, spleen, and kidneys were simulated during targeted radionuclide therapy of lung cancer tissue with iodine-131. Then MAGICA and PAGATA gel dosimeters were placed in the target tissues and their received dose were checked again. The results of these simulations show that the received tissue dose of lungs, liver, breast, stomach, spleen, and kidneys are comparable with the results of MAGICA and PAGATA gel dosimeters; therefore, these gel dosimeters can be used in dosimetry studies of treatment with iodine-131 in physical phantoms.

کلیدواژه‌ها [English]

  • nuclear medicine
  • PAGATA
  • MAGICA
  • Iodine-131
  • polymer gel dosimeter
  • MCNPX

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