برآورد مقدار S جنین در سنین مختلف بارداری ناشی از رادیوداروی پوزیترون‌زا

نویسندگان

1 خراسان رضوی، مشهد، دانشگاه فردوسی مشهد، گروه فیزیک

2 آذربایجان شرقی، تبریز، دانشگاه صنعتی سهند

چکیده

دزسنجی زن باردار تحت تصویربرداری تشخیصی با پرتوهای یون‌ساز، به‌دلیل حساسیت بالای جنین به پرتو و اثرات مخرب پرتو بر جنین بسیار مورد توجه است. در این مطالعه مقادیر S ناشی از رادیوداروی پوزیترون‌زای F-FDG18 در اندام‌های مختلف جنین با استفاده از کد مونت‌کارلوی MCNPX2.6 محاسبه شده است. برای شبیه‌سازی بدن زن باردار و جنین از فانتوم‌های هیبریدی 3، 6 و 9 ماهه استفاده شده است. نتایج نشان می‌دهد که با افزایش سن جنین، مقادیر S جنین ناشی از خودجذبی، کاهش می‌یابد. هنگامی که اندام چشمه در مجاورت جنین واقع شده است، روند کاهشی در صورتی مشاهده می‌شود که فاصله بین اندام چشمه و جنین با افزایش سن جنین افزایش یابد. مقایسه بین داده‌های محاسبه شده در این مطالعه و دیگران روند مشابهی را نشان می‌دهد، گرچه در بعضی موارد اختلاف داده‌ها به‌طور میانگین تا %40 است. این اختلاف به‌دلیل تفاوت هندسه فانتوم مورد استفاده می‌باشد. بنابراین برای تخمین دقیق‌تر دز برای بیمار باردار، تلاش بر این است که در مطالعات آینده روشی برای ساخت فانتوم وابسته به بیمار با استفاده از تعداد محدودی انداز‌ه‌گیری تبیین شود و بدین ترتیب، دقت دز محاسبه شده افزایش یابد.
 

کلیدواژه‌ها

عنوان مقاله [English]

Estimation of fetal S-value for various gestational ages from Positron-emitting radiopharmaceutical

نویسندگان [English]

  • Elie Hoseinian-Azghadi 1
  • Hashem Miri-Hakimabad 1
  • Nadia Zarghi 1
  • Najmeh Mohammadi 2
1
2
چکیده [English]

Dosimetry of a pregnant woman under diagnostic imaging with ionizing radiation is very important due to the high radiosensitivity of the fetus and the destructive effects of radiation on it. In this study, the amount of S-values induced by the positron-emitting radiopharmaceutical 18F-FDG in different fetal organs were calculated using the MCNPX2.6 Monte Carlo code. In the simulations, hybrid phantoms of 3- 6- and 9-month pregnant women were used. The results showed that with increasing the fetal age, the self S-values of fetal organs decrease. A comparison between the calculated data in this study and those reported by other studies showed similar trend, however in some cases the data difference was up to 40% on average. These differences are due to the differences between the geometry of the used phantoms. Therefore, in order to more accurately estimate the dose to pregnant patient and her fetus, we intend to introduce a method for constructing a patient-dependent phantom using a limited number of measurements in our future studies, and thus increasing the accuracy of the calculated dose.

کلیدواژه‌ها [English]

  • Dosimetry
  • Fetal phantom
  • 18F-FDG
  • PET
  • Monte Carlo

مراجع

[1] T. Mokhtarian. Breast Cancer at Pregnancy, Laboratory & Diagnosis, 9(35) (2017) 54-61. [2] D.D. Martin. Review of radiation therapy in the pregnant cancer patient, Clinical obstetrics and gynecology, 54(4) (2011) 591-601. [3] Z. Massomi, S. Khani, M. Gharosian, M. Farhadian and A. Shayan. The prevalence of abnormal Pap smears in females referred to health centers affiliated to medical sciences during the Years 2012 to 2016, Journal of Education and Community Health, 3(2) (2022) 16-22. [4] M.G. Stabin, E.E. Watson, M. Cristy, J.C. Ryman, K.F. Eckerman, J.L. Davis, D. Marshall, and M.K. Gehlen. Mathematical models and specific absorbed fractions of photon energy in the nonpregnant adult female and at the end of each trimester of pregnancy, Oak Ridge National Lab., TN (United States) (1995). [5] J. Chen. Mathematical models of the embryo and fetus for use in radiological protection, Health Physics, 86(3) (2004) 285-295. [6] P. Zanotti-Fregonara, T.M. Koroscil, J. Mantil, and M. Satter. Radiation dose to the fetus from [18F]-FDG administration during the second trimester of pregnancy, Health physics, 102(2) (2012) 217-219. [7] P. Zanotti-Fregonara and M.G. Stabin. New fetal radiation doses for 18F-FDG based on human data, Journal of Nuclear Medicine, 58(11) (2017) 1865-1866. [8] P. Zanotti-Fregonara, M. Chastan, A. Edet-Sanson, O. Ekmekcioglu, E.B. Erdogan, S. Hapdey, E. Hindie and M.G. Stabin. New fetal dose estimates from 18F-FDG administered during pregnancy: standardization of dose calculations and estimations with voxel-based anthropomorphic phantoms, Journal of Nuclear Medicine, 57(11) (2016) 1760-1763. [9] X.G. Xu and K.F. Eckerman. Handbook of anatomical models for radiation dosimetry, (2009). [10] M.R. Maynard, J.W. Geyer, J.P. Aris, R.Y. Shifrin, and W. Bolch. The UF family of hybrid phantoms of the developing human fetus for computational radiation dosimetry, Physics in Medicine & Biology, 56(15) (2012) 4839-4879. [11] M.R. Maynard, N.S. Long, N.S. Moawad, R.Y. Shifrin, A.M. Geyer, G. Fong and W.E. Bolch. The UF Family of hybrid phantoms of the pregnant female for computational radiation dosimetry, Physics in Medicine & Biology, 59(15) (2014) 4325-4343. [12] X.G. Xu, V. Taranenko, J. Zhang and C. Shi. A boundary-representation method for designing whole-body radiation dosimetry models: pregnant females at the ends of three gestational periods-RPI-P3,-P6 and-P9, Physics in Medicine & Biology, 52(23) (2007) 7023-7044. [13] T. Xie and H. Zaidi. Development of computational pregnant female and fetus models and assessment of radiation dose from positron-emitting tracers, European journal of nuclear medicine and molecular imaging, 43(13) (2016) 2290-2300. [14] L. Rafat-Motavalli, H. Miri-Hakimabad and E. Hoseinian-Azghadi. Hybrid pregnant reference phantom series based on adult female ICRP reference phantom, Radiation Physics and Chemistry, 144 (2016) 386-395. [15] ICRP. The 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103. Ann. ICRP 37 (2-4) (2007). [16] E. Hoseinian-Azghadi, L. Rafat-Motavalli and H. Miri-Hakimabad. Development of a 9-months pregnant hybrid phantom and its internal dosimetry for thyroid agents. Journal of radiation research, 55(4) (2014) 730-747. [17] L. Rafat-Motavalli, H. Miri-Hakimabad and E. Hoseinian-Azghadi. Fetal and maternal dose assessment for diagnostic scans during pregnancy. Physics in Medicine & Biology, 61(9) (2016) 3596-3608. [18] L. Rafat Motavalli, E. Hoseinian Azghadi, H. Miri Hakimabad and P. Akhlaghi. Pulmonary embolism in pregnant patients: assessing organ dose to pregnant phantom and its fetus during lung imaging. Medical physics, 44(11) (2017) 6038-6046. [19] L. Rafat-Motavalli, H. Miri-Hakimabad and E. Hoseinian-Azghadi. Dosimetric factors for diagnostic nuclear medicine procedures in a non- pregnant phantom, Journal of Radiological Protection. 38(3) (2018) 908-922. [20] D.B. Pelowitz, J.W. Durkee, J.S. Elson, M.L. Fensin, J.S. Hendricks, M.R. James, R.C. Johns, G.W. McKinney, S.G. Mashnik, J.M. Verbeke and L.S. Waters. MCNPX 2.7. 0 Extensions. Los Alamos National Laboratory, Los Alamos, NM, LA-UR-11-02295, 4 (2011). [21] ICRP. Adult Reference Computational Phantoms. ICRP Publication 110. Ann. ICRP 39 (2) (2009). [22] ICRP. Basic Anatomical and Physiological Data for Use in Radiological Protection Reference Values. ICRP Publication 89. Ann. ICRP 32 (3-4) (2002). [23] M. Zankl, J. Becker, H. Schlattl, N. Petoussi-Henss, K.F. Eckerman, W.E. Bolch and C. Hoeschen. Computational phantoms of the ICRP reference male and reference female. In Proceedings of the 12th Congress of the International Radiation Protection Association (2008) 1-9. [24] ICRP. Radiation Dose to Patients from Radiopharmaceuticals: A Compendium of Current Information Related to Frequently Used Substances. ICRP Publication 128. Ann. ICRP 44(2S) (2015).

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