آسیب کروموزومی ناشی از رادیونوکلئیدهای گسیلنده الکترون‌های اوژه با استفاده از مدل ZBB1 در کد GEANT4

نویسندگان

1 گروه فیزیک، دانشگاه پیام نور واحد تهران، تهران

2 دانشکده مهندسی انرژی و فیزیک، دانشگاه امیرکبیر، تهران

چکیده

وقتی پرتوهای یونیزان وارد سلول زنده می‌شوند، با ماده سلولی تعامل می‌کنند و درنتیجه مقداری از انرژی خود را به آن منتقل می‌کنند. در این مطالعه، انتشار الکترون‌های اوژه و اثرات آن‌ها به‌عنوان آسیب به DNA به‌وسیله برخی از رادیونوکلئیدها مانند 99mTc، 111In، 125I و 123I با استفاده از ابزار Geant4-DNA با مدل 1ZBB مورد بررسی قرار گرفت. مدل 1ZBB از کتابخانه بانک اطلاعات پروتئین انتخاب شده است. تعداد شکست‌های دورشته‌ای به‌عنوان تابعی از انرژی نشان داده شد. در این مطالعه نشان داده شده است که بیش‌ترین آسیب‌ها توسط الکترون‌های اوژه با انرژی‌های کم‌تر از یک کیلوالکترون‌ولت و مربوط به لایه M و Nمی‌باشد.

کلیدواژه‌ها


عنوان مقاله [English]

Calculation of damages of Auger electron emitting from radionuclides based on 1ZBB model: a simulation study using the Geant4 toolkit

نویسندگان [English]

  • Parvin Ahmadi 1
  • Mojtaba Shamsaei Zafae Ghandi 2
  • Aliasghar Shokri 1
1
2
چکیده [English]

When an ionizing beam enters a, it interacts with the cellular material, thereby transferring some of its energy to the living cell. In this study, the propagation of Auger electrons and their effects as DNA damage by some radionuclides, were analyzed using the Geant4-DNA Toolkit with the 1ZBB model. The 1ZBB model is selected from the protein data bank library which simulates the location of atoms in the sequence of cellular chromosomes. The average number of DSBs is shown as a function of energy. In this study, it is shown that the most damage is caused by Auger electrons with energies of less than 1 keV which corresponds to Auger electrons in layers M, N.
 

کلیدواژه‌ها [English]

  • Geant4-DNA
  • Double Strand Break
  • Single Strand Break
  • Auger electron
  • Simulation
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