بررسی آسیب‌های مستقیم نوترون‌های با انرژی 0/1 تا 2 مگا الکترون ولت، بر ساختار اتمی مولکول DNA با ابزار Geant4

نویسندگان

1 دانشگاه بوعلی سینا همدان

2 دانشگاه پیام نور تهران

3 مرکز تحقیقات بیوشیمی و بیوفیزیک دانشگاه تهران

4 سازمان انرژی اتمی

10.22052/7.1.1

چکیده

مطالعه‌ی حاضر به بیان روشی برای تخمین اثربخشی بیولوژیکی نسبی، RBE، نوترون‌های سریع با استفاده از شبیه‌سازی مونت کارلو می‌پردازد. این رهیافت بر اساس ترکیب یک مدل با دقت اتمی از هندسه مولکول DNA و شبیه‌سازی به روش مونت کارلو برای ردیابی ذرات است. موقعیت دقیق مکانی اتم‌های مولکول DNA از بانک داده پروتئینی استخراج گشته است. ابزار Geant4 برای ردیابی ذرات ثانویه تولید شده توسط نوترون‌های سریع در برهمکنش‌شان با آب مایع استفاده گردید. به­ دلیل استفاده از طیف انرژی ذرات ثانویه به ­جای تابش مستقیم نوترون، زمان محاسبات به طور محسوسی کاهش یافت. شکست رشته‌ای دوگانه به­ عنوان مؤثرترین نوع آسیب، برای تخمین RBE نوترون‌ها، استفاده شد. پرتوهای گامای کبالت 60 به ­عنوان تابش مرجع برای محاسبه RBE در نظر گرفته شدند. مدل در توصیف رفتار RBE و محل RBEmax بر اساس توزیع انرژی نوترون‌ها موفق بوده است.
 

کلیدواژه‌ها


عنوان مقاله [English]

An investigation of neutron direct damages at energies of 0.1-2 MeV on the DNA molecules with atomic structure deduced using Geant4 toolkit

نویسندگان [English]

  • Azam Zabihi 1
  • Ghasem Forozani 2
  • Farid Semsarha 3
  • Amir Moslehi 4
  • Peyman Rezaeian 4
1
2
3
4
چکیده [English]

This study proposes a method to estimate RBE of fast neutrons using Monte Carlo simulations. This approach is based on the combination of an atomic resolution DNA geometrical model and Monte Carlo simulations for tracking particles. Atomic positions were extracted from the Protein Data Bank. The GEANT4 code was used for tracking the secondary particles generated by fast neutrons during their interaction with liquid water. Since secondary particles spectra were used instead of simulating the interaction of neutrons explicitly, this method reduced the computation time dramatically. Double strand break induction was used as the endpoint for the estimation of fast neutrons relative biological effectiveness (RBE).60Co γ -rays were used as the reference radiation quality. The model succeeded in reproducing the behavior of the RBE and the position of RBEmax as a function of the incident neutron energy between 0.1 MeV to 2 MeV.

کلیدواژه‌ها [English]

  • Monte Carlo
  • Neutron
  • RBE
  • Geant4-DNA
  • PDB
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