شبیه‌ساز تومور فعال سازی شده توسط نقره و برآورد بهبود دز در فوتون درمانی

نویسندگان

1 دانشگاه پیام نور سقز

2 دانشگاه حکیم سبزواری

3 دانشگاه پیام نور تهران

10.22052/5.3.51

چکیده

درمان تومور با استفاده از عناصر فعال‌ساز روشی است که افق­ های جدیدی را در رادیوتراپی نوید می‌دهد. به­ دلیل وجود پارامترهای مختلف و شرایط فیزیکی متنوع در این روش درمانی، استفاده از مدل­ های شبیه­ سازی، آسان­تر، کم ­هزینه­ تر و سریع­تر از روش ­های عملی برای پیش­بینی راهکارهای بهینه ­سازی طراحی درمان می‌باشد. بنابراین در این مطالعه از شبیه‌ساز‌های مونت کارلو جهت بررسی کمی ‌افزایش دز و عوامل مؤثر بر فوتون درمانی در تومور فعال‌شده توسط نانوذرات نقره استفاده شده ­است. همچنین منظور کردن ترکیب دقیق و توالی بافت‌های متفاوت کار اصلی این مقاله است. برای این منظور فانتوم سر با ترکیبات واقعی آن توسط کد MCNPX مدل شد. تومور معمولی و تومور فعال‌شده توسط نانوذارت نقره شبیه‌سازی شدند. در این تحقیق فرض شد که نانوذرات به طور همگن در تومور توزیع شده باشند. محاسبات دز و بهبود آن در فوتون درمانی محاسبه گردیدند. نتایج بهبود دز را در تومور فعال‌شده توسط نانوذرات نقره نشان می‌دهند. وابستگی این پارامتر به غلظت، یک وابستگی خطی می‌باشد. هرچند انرژی لبه k نقره 53/25 کیلو الکترون­ولت است اما انرژی بهینه بین 35 تا 45 کیلو الکترون­ولت قرار دارد. همچنین مشخص شد که با افزایش عمق، فاکتور بهبود دز کاهش می‌یابد.

کلیدواژه‌ها


عنوان مقاله [English]

Simulation of silver nanoparticle radio-sensitized tumor and evaluation of dose enhancement in photon therapy

نویسندگان [English]

  • somaye malmir 1
  • Ali asghar Molavi 2
  • Saeed Mohammadi 3
چکیده [English]

Treatment of radio-sensitized tumor is one of the promising modalities in radiotherapy. Since the different parameters and physical conditions vary in the treatments, the use of simulation models is easier, less costly and faster than practical methods for forecasting the solutions designed to optimize treatment. Therefore in this study, Monte Carlo simulations are applied to investigate the dose enhancement and the influential factors in photon therapy of silver nanoparticle radio-sensitized tumor. Consideration of the exact composition and sequence of the different tissues is the main task of this article. Head phantom with its actual composition was modeled by MCNPX code. Common tumor and silver nanoparticle radio-sensitized tumor are simulated. In this study, it was assumed that nanoparticles in the tumor are distributed homogeneously. Dose Calculation and its enhancement in photon therapy were calculated. The results show improved dose in the silver nanoparticles radio-sensitized tumor. This parameter is a linear function of concentration. Although silver k edge energy is 25.53 KeV, but optimized energy is between 35 to 45 KeV. Moreover, it is concluded that dose enhancement decreases by increasing the tumor depth.

کلیدواژه‌ها [English]

  • Photon therapy
  • Silver nanoparticles
  • Dose enhancement
  • Sensitized tumor
  • Monte Carlo calculations
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