بررسی تغییر میزان آسیب‌های DNA تحت تابش پروتون درحضور نانوذرات مختلف طلا، گادولینیوم و ید با استفاده از ابزار Geant4-DNA

نویسندگان

1 گروه مهندسی هسته‌ای-پرتوپزشکی، دانشگاه آزاد اسلامی واحد علوم و تحقیقات تهران، تهران

2 پژوهشگاه علوم و فنون هسته‌ای، تهران

چکیده

پرتودرمانی یکی از روش‌های مؤثر در درمان سرطان است. استفاده از پروتون و یون‌های سبک در درمان پرتویی به‌علت برهم‌کنش فیزیکی متفاوت نسبت به فوتون‌ها و اعمال دز متمرکز در ناحیه براگ در حال توسعه می‌باشد. با این حال ارائه روش‌های نوین در افزایش بازده درمان همواره مورد توجه بوده است. یکی از این روش‌ها، افزودن نانوذرات مواد با عدد اتمی بالا به بافت است که ضمن افزایش عدد اتمی مؤثر بافت، موجب ارتقاء دز مؤثر در زمان درمان پرتویی و ایجاد آسیب‌های بیشتر در DNA بافت هـدف می‌گردد. در این مقـاله با اسـتفاده از ابزار Geant4-DNA، مولکول B-DNA با فرمت بانک اطلاعاتی پروتئین، (PDB) را در هندسه شبیه‌سازی توزیع نموده و آسیب‌های وارده از طریق برهم‌کنش پروتون در گستره انرژی ۱/۰ تا MeV ۲۰ را محاسبه کرده‌ایم. تعداد و بازده آسیب‌های تک‌رشته‌ای (SSB) و دورشته‌ای (DSB) با درنظر گرفتن برهم‌کنش‌های مستقیم و غیرمستقیم با/ بدون حضور نانوذرات محاسبه شده است. با مقایسه مشاهده شد که نتایج محاسبات بدون نانوذرات با نتایج حاصل از پژوهش‌های قبلی سازگاری خوبی دارد. نتایج به‌دست آمده از این تحقیق، افزایش آسیب‌ها تا 15 درصد برای آسیب‌های تک‌رشته‌ای و تا 80 درصد برای آسیب‌های دورشته‌ای را در حضور نانوذرات طلا نشان می‌دهد. هم‌چنین میزان آسیب‌های DNA در حضور نانوذرات ید و گادولینیوم به‌ترتیب با 7 و 13 درصد کاهش نسبت به طلا مشاهده شدند. نتایج حاصل از این تحقیق نشان می‌دهد نانوذرات می‌توانند با هدف بهبود اثربخشی درمان پرتوی مورد استفاده قرار‌ گیرند.

کلیدواژه‌ها


عنوان مقاله [English]

Investigation of the extent of DNA damage under proton irradiation in the presence of various nanoparticles of Au, Gd and I, using Geant4-DNA toolkit

نویسندگان [English]

  • Seyed Javad Hosseini-AliAbadi 1
  • Daryush Sardari 1
  • Elham Saeedzade 1
  • Samaneh Baradaran 2
1
2
چکیده [English]

Radiation therapy is one of the most effective methods in the treatment of cancer. The use of protons and light ions in radiation therapy is developing due to the different physical interactions with the photons and the application of concentrated doses in the Bragg region. However, new methods to increase the efficiency of treatment have always been considered. One is addition of nanoparticles of high-Z materials to the tissue, which while increasing the effective atomic number of the tissue, increases the effective dose during radiation therapy and causes more damage to the DNA. In this study, using the Geant4-DNA toolkit, we defined B-DNA as PDB format in the geometry. DNA damages after proton interactions in the energy range of 0.1 to 20 MeV were calculated. The number and efficiency of single-strand breaks (SSB) and double-strand breaks (DSB) have been calculated by considering direct and indirect interactions with / without the presence of nanoparticles. By comparison, it was found that the obtained results without nanoparticles are well consistent with previous studies. The results of this study show an increase of up to 15% for single-strand damage and up to 80% for double-strand breaks in the presence of gold nanoparticles. Also, the amount of DNA damage in the presence of iodine and gadolinium nanoparticles was reduced by 7% and 13% compared to gold, respectively. The results of this study show that nanoparticles can be used to improve the effectiveness of radiation therapy.

کلیدواژه‌ها [English]

  • Proton therapy
  • Single Strand Break
  • Double Strand Break
  • Nanoparticles
  • DNA
  • Geant4-DNA
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