Investigating the feasibility of breast cancer detection using a Synchrotron accelerator through X-ray fluorescence spectrometry (XRF) technique on hair and nail samples

Document Type : Original Article

Authors

1 Department of Physics Faculty of Basic Sciences, Imam Khomeini International University, Qazvin, Iran

2 Iran Light Source Facilities, Basic Sciences Research Institute, Tehran, Iran

Abstract

Breast cancer is one of the most common concerns of human societies, which is unfortunately spreading, and today it is the most common cancer in women and the second cause of death after lung cancer. As a result, early detection of cancer is one of the most effective steps in the definitive treatment of cancer in the world. In this study, X-ray fluorescence spectroscopy was performed using synchrotron accelerator on hair and nail samples in order to compare the concentration of zinc, calcium and sulfur elements in the samples of healthy women and breast cancer patients. Healthy samples were collected from women who did not have any signs of breast cancer in physical examinations and mammography imaging, and cancer samples were collected from people who had signs of malignant cancerous tumors with conventional methods such as mammography and biopsy. The results of this study were obtained from X-ray fluorescence spectroscopy at the Ultra Synchrotron located in Trieste, Italy, which indicates a significant decrease in zinc in hair samples and a significant increase in sulfur in nail samples of breast cancer patients compared to healthy individuals, while in No significant changes were observed in the calcium level.

Keywords

References

1. W. Majeed, B. Aslam, I. Javed, T. Khaliq, F. Muhammad, A. Ali, A. Raza. Breast cancer: major risk factors and recent developments in treatment. Asian Pac. J. Cancer. Prev. 15 (8) (2014) 3353-3358.
2. R. A. Jesinger. Breast anatomy for the interventionalist. Tech. Vasc. Interv. Radiol. 17 (1) (2019) 3-9.
3. G. N. Sharma, R. Dave, J. Sanadya, P. Sharma, K. K. Sharma. Various types and management of breast cancer: an overview. J. Adv. Pharm. Technol. Res. 1 (2) (2010) 109.
4. Y. S. Sun, Z. Zhao, Z. N. Yang, F. Xu, H. J. Lu, Z. Y. Zhu, W. Shi, J. Jiang, P. P. Yao, H. P. Zhu. Risk factors and preventions of breast cancer. Int. J. Biol. Sci. 13 (11) (2017) 1387.
5. J. Ma, A. Jemal. Breast cancer statistics. Breast Cancer Metastasis and Drug Resistance: Springer (2013) 1-18.
6. M. I. Nounou, F. ElAmrawy, N. Ahmed, K. Abdelraouf, S. Goda, H. Syed-Sha-Qhattal. Breast cancer: conventional diagnosis and treatment modalities and recent patents and technologies. Breast Cancer Basic Clin. Res. 9 (2015).
7. L. Wang. Early diagnosis of breast cancer. Sensors 17 (7) (2017) 1572.
8. A. B. Nover, S. Jagtap, W. Anjum, H. Yegingil, W. Y. Shih, W. H. Shih, A. D. Brooks. Modern breast cancer detection: a technological review. Int. J. Biomed Imaging 2009 (2009) 902326.
9. N. E. Allen, J. S. Morris, R. A. Ngwenyama, T. J. Key. A case–control study of selenium in nails and prostate cancer risk in British men. Br. J. Cancer 90 (7) (2004) 1392-1396.
10.F. Larner, L. N. Woodley, S. Shousha, A. Moyes, E. Humphreys-Williams, S. Strekopytov, A. N. Halliday, M. Rehkämper, R. C. Coombes. Zinc isotopic compositions of breast cancer tissue. Metallomics 7 (1) (2015) 112-115.
11.L. Jouybari, F. Kiani, A. Akbari, A. Sanagoo. A meta-analysis of zinc levels in breast cancer. J. Trace. Elem. Med. Biol. 56 (2019) 90-99.
12.X. Wu, J. Tang, M. Xie. Serum and hair zinc levels in breast cancer: a meta-analysis. Sci. Rep. 5 (2015) 12249.
13.A. Maziar, D. Shahbazi-Gahrouei, M. B. Tavakoli, V. Changizi. Non invasive XRF analysis of human hair for health state determination of breast tissue. Iran. J. Cancer Prev. 8 (6) (2015).
14. Z. W. Chen, W. M. Gibson, H. Huang. High definition x-ray fluorescence: principles and techniques. X-ray Optics. Instr. 2008 (2008) 318171.
15. R. Zhang, L. Li, Y. Sultanbawa, Z. P. Xu. X-ray fluorescence imaging of metals and metalloids in biological systems. Am. J. Nucl. Med. Mol. Imaging 8 (3) (2018) 169.
16. R. Jenkins. X-ray fluorescence spectrometry. J. Anal. At. Spectrom. 2 (1999) 1773-1799.
17. B. Beckhoff, B. Kanngießer, N. Langhoff, R. Wedell, H. Wolff. Handbook of Practical X-ray Fluorescence Analysis. Springer Science & Business Media, Berlin, 2007.
18. A. Iida. Synchrotron Radiation X-Ray Fluorescence Spectrometry. Encyclopedia Analyt. Chem. Appl. Theor. Instr. (2006) 1-23.
19. A. C. Thompson, D. Vaughan. (Eds.) X-Ray Data Booklet. LBNL, University of California, Berkeley, 2001.
20. S. K. Lwanga, S. Lemeshow. Stanley & World Health Organization. Sample size determination in health studies: a practical manual / S. K. Lwanga and S. Lemeshow. World Health Organization, 1991.
21. IAEA Sampling. Storage and sample preparation procedures for X-ray fluorescence analysis of the environmental materials. IAEA. Vienna, 1997.
22. T. Oyama, K. Matsuno, T. Kawamoto, T. Mitsudomi, T. Shirakusa, Y. Kodama. Efficiency of serum copper/zinc ratio for differential diagnosis of patients with and without lung cancer. Biol. Trace. Elem. Res. 42 (2) (1994) 115-127.
23. A. Q. Truong-Tran, L. H. Ho, F. Chai, P. D. Zalewski. Cellular zinc fluxes and the regulation of apoptosis/genedirected cell death. J. Nutr. 130 (5) (2000) 1459S-1466S.
24. L. A. Saryan, D. T. Minkel, P. J. Dolhun, B. L. Calhoun, S. Wielgus, M. Schaller, D. H. Petering. Effects of zinc deficiency on cellular processes and morphology in Ehrlich ascites tumor cells. Cancer Res. 39 (7) (1979) 2457-2465.
25. K. Geraki, M. J. Farquharson, D. A. Bradley. Concentrations of Fe, Cu and Zn in breast tissue: a synchrotron XRF study. Phys. Med. Biol. 47 (13) (2002) 2327.
26. R. S. MacDonald. The role of zinc in growth and cell proliferation. J. Nutr. 130 (5) (2000) 1500-1508.
27. B. E. Golden. Zinc in cell division and tissue growth: physiological aspects. In: Zinc in Human Biology, Springer, London (1989) pp. 119-128.
28. H. W. Kuo, S. F. Chen, C. C. Wu, D. R. Chen, J. H. Lee. Serum and tissue trace elements in patients with breast cancer in Taiwan. Biol. Trace. Elem. Res. 89 (1) (2002) 1-11.
29. K. Geraki, M. J. Farquharson, D. A. Bradley. Concentrations of Fe, Cu and Zn in breast tissue: a synchrotron XRF study. Phys. Med. Biol. 47 (13) (2002) 2327. 

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