Department of Physics, Faculty of Sciences, University of Guilan, Rasht, Iran
Abstract
The Tc-99m DMSA is one of the most widely used radiopharmaceuticals in nuclear medicine. This radiopharmaceutical is used to study the location, size, shape, and function of the kidneys. In this paper, the absorbed doses of different organs and the effective dose after injection of this radiopharmaceutical have been calculated using the MIRD method. For this purpose, the specific absorbed fractions have been obtained for adult phantom of revised ORNL phantom series using Monte Carlo simulations, and then the S values for the Tc-99m radionuclide have been calculated. Finally, the absorbed doses of different organs have been calculated using the biokinetic data of ICRP 53 for Tc-99m DMSA. The results show that the kidneys, bladder wall, spleen, and adrenal glands receive the highest absorbed dose after injection of Tc-99m DMSA. Also, the effective dose per unit activity administered is estimated to be 1.60E-02 mSv/MBq.
G. B. Saha. Fundamentals of Nuclear Pharmacy. 6th ed. Springer, New York, 2010.
D. Hernández-Valdés, A. Blanco-González, A. García-Fleitas, Z. Rodríguez-Riera, G. Meola, R. Alberto, et al. Insight into the structure and stability of Tc and Re DMSA complexes: A computational study. J. Mol. Graphics Modelling. 71 (2017) 167-75.
E. Tsukamoto, K. Itoh, C. Katoh, T. Mochizuki, T. Shiga, K. Morita, et al. Validity of 99mTc-DMSA renal uptake by planar posterior-view method in children. Ann. Nucl. Med. 13 (1999) 383-387.
W. E. Bolch, K. F. Eckerman, G. Sgouros, S. R. Thomas. A generalized schema for radiopharmaceutical dosimetry--standardization of nomenclature, MIRD pamphlet No. 21. J. Nucl. Med. 50 (2009) 477-84.
E. Y. Han, W. E. Bolch, K. F. Eckerman. Revisions to the ORNL series of adult and pediatric computational phantoms for use with the MIRD schema. Health Phys. 90 (2006) 337-56.
M. Cristy, K. F. Eckerman. Specific absorbed fractions of energy at various ages from internal photon sources. Oak Ridge, TN: Oak Ridge National Laboratory.ORNL/TM-8381/V1. 1987.
ICRP. Basic anatomical and physiological data for use in radiological protection: reference values: ICRP Publication 89. Ann. ICRP. 32 (2002).
ICRU. Photon, Electron, Proton and Neutron Interaction Data for Body Tissues; ICRU Report 46. Journal of the International Commission on Radiation Units and Measurements. 24 (1992).
W. S. Snyder, M. R. Ford, G. G. Warner, S. B. Watson. "S," absorbed dose per unit cumulated activity for selected radionuclides and organs; MIRD Pamphlet 11. Society of Nuclear Medicine, New York, 1975.
E. Y. Han. Revised series of stylized anthropometric phantoms for internal and external radiation dose assessment, Ph.D. Thesis, University of Florida, 2005.
Sadremomtaz, A., & sadfarnejad, F. (2023). The Calculation of absorbed dose due to kidneys scan with Tc-99m DMSA. Journal of Radiation Safety and Measurement, 11(5), 73-77.
MLA
Alireza Sadremomtaz; Farzin sadfarnejad. "The Calculation of absorbed dose due to kidneys scan with Tc-99m DMSA", Journal of Radiation Safety and Measurement, 11, 5, 2023, 73-77.
HARVARD
Sadremomtaz, A., sadfarnejad, F. (2023). 'The Calculation of absorbed dose due to kidneys scan with Tc-99m DMSA', Journal of Radiation Safety and Measurement, 11(5), pp. 73-77.
VANCOUVER
Sadremomtaz, A., sadfarnejad, F. The Calculation of absorbed dose due to kidneys scan with Tc-99m DMSA. Journal of Radiation Safety and Measurement, 2023; 11(5): 73-77.
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