Determination of the absorbent dose increase factor for different concentrations of gold nanoparticles using a dosimetry gel

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Abstract

with the advancement of nanotechnology, high-atomic materials such as gold nanoparticles can be used to increase the amount of absorbed doses and use this property to eliminate cancer cells. In this study, the dose enhancement factor (DEF) derived from different concentrations of gold nanoparticles was calculated to show an increase in absorbed dose from gold nanoparticles. At first, a tissue equivalent gel (MAGIC-f) was made at the University of Mazandaran's Nuclear Physics Laboratory, and the gold nanoparticles were added to the gel with appropriate concentrations. Vials containing gel and nano-gel were exposed to X-ray radiation of 6 MV of Siemens linear accelerator. After reading the gel with the optical CT scan imaging system, the DEF for nanoparticles was estimated for concentrations, 0.1, 3 and 6 mM. Iit was concluded that increasing the concentration of gold nanoparticles would increase the absorbed dose.

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