Internal dosimetry of radioiodine using ICRP reference phantoms and updated biokinetic model

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Abstract

The purpose of this study is to estimate internal dose to human body due to administration of I-131 using new biokinetic model of iodine. In this respect, we used international commission on radiological protection (ICRP) adult reference phantoms. Monte Carlo calculations were performed using MCNPX 2.6 code. The average dose to target organ per disintegration inside source organ, namely S factor, was estimated using F6 and *F8 tallies, and then compared to those from previous studies. The results show that the difference between S factors is on average less than 8%. Furthermore, the variations caused by different 131I decay spectrums were investigated. Finally, the absorbed and the effective doses were obtained for adult female and male ICRP reference phantoms considering two biokinetic models. To conclude, using different tallies and decay spectrums, as well as, various biokinetic models could affect considerably on the amount of estimated internal dose.
 

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[1] Lamart, Stephanie, et al. "S values for 131-I based on the ICRP adult voxel phantoms." Radiation protection dosimetry 110-92:(2016) 161,1. [2] ICRP, 1991. 1990 Recommendations of the International Commission on Radiological Protection. ICRP Publication 60 (Users Edition). [3] Bolch W E, Eckerman K F, Sgouros G, and Thomas S R. MIRD pamphlet no. 21: a generalized schema for radiopharmaceutical dosimetry—standardization of nomenclature. J Nucl Med 50(3) (2009) 477-484. [4] Leggett, Richard Wayne. "A physiological systems model for iodine for use in radiation protection." Radiation research 174.4 (2010): 496-516. [5] ICRP, 2009. Adult Reference Computational Phantoms. ICRP Publication 110. Ann. ICRP 39 (2). [6] Lamart S, Bouville A, Simon S L, Eckerman K F, Melo D, Lee C. (2011) Comparison of internal dosimetry factors for three classes of adult computational phantoms with emphasis on I-131 in the thyroid. Phys Med Biol 56, 7317–7335 [7] ICRP, 2008. Nuclear Decay Data for Dosimetric Calculations. ICRP Publication 107. Ann. ICRP 38 (3).interaction data for body tissues, with data disk, ICRU Report 46D, Bethesda-Maryland, USA, (1992).

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