Position optimization of brachytherapy sources at 2D and 3D using genetic algorithm

Authors

10.22052/1.3.15

Abstract

Optimization in radiotherapy is one of an important and attractive topic in Medical Physics. In this study, we have written a computer code base on genetic algorithm using MATLAB software, to optimize the best places of brachytherapy sources with optimal value of a parameter which is determined by weight. The weight parameter is related to the activity of each seed implant brachytherapy sources, such as iodine -125, or the irradiation time in each place after loading brachytherapy source like Iridium-192. We have run the code for some arbitrary tumor’s shapes in two and three dimensions spaces and the optimized places for seeds of Ioine-125 brachytherapy source and their activities are founded. For each tumor, the optimization is done so that the points on the boundary edge of two-dimensional or three-dimensional object, points on the surface and all points within a given dose greater or equal to the dose on the surface or in the border areas have. The Isodose curves show the result of dose optimization is done at the desirable level.

Keywords


[1] Häfeli U. O., Roberts W. K., Meier D. S. et al., "Dosimetry of a W-188/Re-188 beta line source for endovascular brachytherapy" Medical Physics,Vol. 27, No. 4, 2000, pp. 668-675. [2] Udale-Smith M., "Monte Carlo calculations of electron beam parameters for three Philips linear accelerators", Physics in Medicine & Biology, Vol. 37, No. 1, 1992, pp. 85–105. [3] Karaiskos P., Angelopoulos A., Baras P., Rozaki-Mavrouli H., Sandilos P., et al., "Dose rate calculations around 192Ir brachytherapy sources using a Sievert integration model", Physics in Medicine & Biology, Vol. 45, No. 2, 2000, pp. 383–398. [4] Gifford K. A., Mourtada F., Cho S. H., Lawyer A., Horton J. L., "Monte Carlo calculations of the dose distribution around a commercial gynecologic tandem applicator', Radiother Oncol, Vol. 77, No. 2, 2005, pp. 210–215. [5] Mowlavi A. A., Cupardo F., Severgnini M., "Monte Carlo and experimental relative dose determination for an Ir-192 source in water phantom", Iranian Journal of Radiation Research, Vol. 6, No. 1, 2008, pp. 37–42. [6] Ling C. C., Schell M. C., Yorke E. D., Palos B. B., Kubiatowicz D. O., "Two-dimensional dose distribution of 125I seeds", Medical Physics, Vol. 12, No. 5, 1985, pp. 652-655. [7] Singh V., Mukherjee L., Xu J., Hoffmann K. R., Dinu P. M., Podgorsak M., "Brachytherapy seed localization using geometric and linear programming techniques", IEEE Transactions of Medical Imaging, Vol. 26, No. 9, 2007, pp. 1291-304. [8] AAPM Report No. 21, "Recommendations of AAPM Task Group 32: Specification of Brachytherapy Source Strength", New York: American Institute of Physics, 1987. [9] Williamson J. F., Thomadsen B. R., Nath R., editors, "Brachytherapy Physics", Medical Physics Publishing, Madison WI, 1995. [10] Nath R., Anderson L. L., Luxton G., Weaver K. A., Williamson J. F., Meigooni A.S., "Dosimetry of interstitial brachytherapy sources: recommendations of the AAPM Radiation Therapy Committee Task Group No. 43", Medical Physic, Vol. 22, No. 2, 1995, pp. 209–234. [11] Meyer R. R., D’Souza W. D., Ferris M. C., Thomadsen B. R., "MIP models and BB strategies in brachytherapy treatment optimization", Journal of Global Optimization, Vol. 25, No. 1, 2003, pp. 23–42. [12] Kolkman-Deurloo I. K. K., Visser A. G., Niël C. G., Driver N., Levendag P.C., "Optimization of interstitial volume implants", Radiotherapy and Oncology, Vol. 31, No. 3, 1994, pp. 229–239. [13] Saw C. B., Suntharalingam N. "Quantitative assessment of interstitial implants", International Journal of Radiation Oncology Biology Physics, Vol. 20, No. 1, 1991, pp. 135–39. [14] Morton G. C., Sankreacha R., Halina P., Loblaw A., "A comparison of anatomy–based inverse planning with simulated annealing and graphical optimization for high-dose-rate prostate brachytherapy", Brachytherapy, Vol. 7, No. 1, 2008, pp. 12–16. [15] Chaswal V., Yoo S., Thomadsen B. R., Henderson D. L., "Multi-species prostate implant treatment plans incorporating 192Ir and 125I using a Greedy Heuristic based 3D optimization algorithm", Medical Physic, Vol. 34, No. 2, 2007, pp. 436–44. [16] Shwetha B., Ravikumar M., Katke A., Supe S. S., VenkataGiri G., Ramanand N., Pasha T., "Dosimetric comparison of various optimization techniques for high dose rate brachytherapy of interstitial cervix implants", Journal of Applied Clinical Medical Physics, Vol. 11, No. 3, 2010, pp. 225-230. [17] Alterovitz R., Lessard E., Pouliot J., Hsu I. C. J., O’Brien J. F., Goldberg K., "Optimization of HDR brachytherapy dose distributions using linear programming with penalty costs", Medical Physics, Vol. 33, No. 11, 2006, pp. 4012-4019. [18] De Boeck L., Beliën J., Egyed W., "Center for Modeling and Simulation" , HUBrussel, Brussels, Belgium, 2011, Available online at: https://lirias.hubrussel.be/bitstream/123456789/5208/1/11HRP32.pdf