Journal of Radiation Safety and Measurement

Journal of Radiation Safety and Measurement

Magnetic Hyperthermia Treatment of Lung Cancer Using Fe₃O₄ Nanoparticles with Silver Shielding for Cardiac Protection

Document Type : Original Article

Authors
Kazhal Moetamedi 1
Mohammad Hossein Tavakoli 1
Safoora Nikzad 2
Zahra Keshtpour Amlashi 3
1 Department of Physics, Faculty of Sciences, Bu-Ali Sina University, Hamedan, Iran
2 Isfahan University of Medical Sciences, Hezar Jerib Avenue, Isfahan, Iran
3 Cancer Research Center, Institute of Cancer, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran
10.22052/rsm.2025.257245.1141
Abstract
Magnetic hyperthermia using Fe₃O₄ nanoparticles offers a targeted and minimally invasive strategy for lung cancer treatment. In this study, a two dimensional computational model was developed in COMSOL Multiphysics 6.1 to simulate heat generation by uniformly distributed Fe₃O₄ nanoparticles under a 300 kHz, 150 A alternating magnetic field. The model incorporated anatomically realistic domains representing the lung, tumor, and heart tissues, along with a silver shielding layer designed to attenuate magnetic flux and protect the heart from excessive heating. Electromagnetic and thermal behavior were modeled using Maxwell’s equations and a porous-media form of Pennes’ bioheat equation, accounting for blood perfusion, respiratory airflow, and metabolic heat generation. Simulation results demonstrated that the tumor core reaches therapeutic hyperthermia levels (43–46 °C), while the silver shield effectively maintains cardiac temperatures below 39 °C. Temperature gradients at the tumor margins, caused by convective cooling, highlight the importance of optimizing nanoparticle concentration and field intensity. This model provides a physiologically realistic and computationally validated framework that enhances the safety and efficacy of magnetic hyperthermia, supporting its potential translation into clinical applications.
Keywords
Magnetic hyperthermia
Fe3O4 nanoparticles
Lung cancer treatment
Silver shielding
Cardiac protection
Electromagnetic simulation
Heat transfer
Targeted therapy
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